Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

大学经典推荐书目的遴选标准与发展特点     

张微 《图书情报工作》2020,64(7):67-72

[目的/意义] 经典阅读处于学生通识教育的核心环节，大学经典推荐书目在"读什么""怎么读"的核心教育环节发挥着重要作用。分析和确立大学经典推荐书目的遴选标准，探究其发展特点，对于优化经典书目编制、推动经典阅读，具有十分重要的意义。[方法/过程] 通过网络调研和电话访谈梳理部分"双一流"高校的官方经典推荐书目，分析我国高校经典推荐书目的产生过程与背景。[结果/结论] 大学经典推荐书目在遴选上重视中国传统经典，也注重借鉴西方经典；人文社会科学经典与自然科学经典遴选相对均衡；发掘元典书目新生，重视充实有价值的影响书目。同时，在阅读推广实践中，呈现出尊重阅读主体、重视首因效应发挥、丰富创新推介载体，以及差异化、层次化、定制化的发展特点，体现出高校党政领导的重视和图书馆的主动作为。  相似文献   

Dealing with disagreement: The roles of topic familiarity and disagreement explanation in evaluation of conflicting expert claims and sources     

《Learning and Instruction》2020

Learners may increasingly encounter conflicting expert reports. However, little is known about how they deal with this challenge. We examined how learners' familiarity with a controversial historical topic affects their epistemic judgments of conflicting expert claims and sources, the interplay of their claim and source evaluation strategies, and their meta-epistemic understanding of the legitimacy of the disagreement (absolutist, multiplist, and evaluativist perspectives). In two studies, topic familiarity increased agreement with belief-consistent expert claims and the perceived trustworthiness of the expert who presented these claims. Topic familiarity also impacted the coordination of evaluation strategies and led to greater reliance on knowledge-based validation. However, topic familiarity did not affect meta-epistemic understanding of the legitimacy of the controversy. In the second study, reading an explanation about reasons for disagreements between historians resulted in higher evaluativism. Teaching about expert disagreement may be a productive approach for promoting appreciation of the diversity of knowledge.  相似文献   

Recording the war effort: immigrant communities in Latin America and the memory of the Great War     

María Inés Tato 《档案与原稿》2020,48(2):200-215

ABSTRACT

This paper aims to analyse the initiatives undertaken by some immigrant communities residing in Latin America to record their mobilisation around the First World War. After the armistice, European communities in Argentina, Bolivia, Brazil, Chile, Mexico, Paraguay, Peru, Uruguay and other countries gathered detailed information about their activities during the conflict, published as profusely illustrated books of remembrance, offered to their governments as proof of their loyalty. The article intends to establish the peculiar nature of these publications as records of the war effort, and analyse the agents and processes of their elaboration, and their role as commemorative but also as archival documents.  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

侧向滑步推铅球技术教学中运用双语教学法的实验研究   总被引：1，自引：0，他引：1  

王平  郑兵  王延奇 《首都体育学院学报》2003,15(3):70-71

作者运用双语教学在体育教育专业侧向滑步推铅球技术教学中进行了教学尝试，通过对教学后实验组与对照组在技评和达标两项考核指标的统计分析，提出双语教学法运用于铅球技术教学中是可行的，同时，对运用双语教学的方法作了简述。  相似文献   

谈谈高校外文图书采访改革   总被引：15，自引：0，他引：15  

韩冬丽 《江西图书馆学刊》2003,33(2):21-22

外图书采访一直是高校图书馆献资源建设的重点之一，结合本馆外图书采访的实际工作经验，提出改革外图书采购模式的若干看法。  相似文献   

加强和改进体育院校青年教师党员发展工作管见     

胡友权 《武汉体育学院学报》2003,37(5):161-163

按照“三个代表”的要求和与时俱进的观点，认为搞好体育院校青年教师党员发展工作，首先要统一思想，深刻认识其重要性和紧迫感；第二，正视现实，增强其主动性和责任感；第三，明确思路，抓住重点，扎扎实实把工作做细做好。围绕这三个方面，理论结合实践进行了分析与探讨。  相似文献   

对《体育与健康》课程学习和成绩评定的理论研究   总被引：2，自引：0，他引：2  

林志辉 《福建体育科技》2003,22(5):58-60

本文以《体育与健康》新课程为主线,为如何建构体育教育中的学生学习评价和成绩评定体系提出了一些看法和意见。其目的是为了进一步深化体育教学改革,提高体育教学质量,提供理论依据。  相似文献